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Dr. Jayakumar Rajadas, Ph.D.DirectorPhone: (650) 724-6806 |
Director - Biomaterials and Advanced Drug Delivery Laboratory (BioADD)
Assistant Director - Cardiovascular Pharmacology Division, Cardiovascular Institute
Lecturer - Neurology and Neurological Sciences
Stanford University School of Medicine
Dr. Rajadas is currently working on the molecular mechanism of neurodegenerative disorders caused by aggregated tau and abeta proteins-proteins that are synergically involved in Alzheimer’s disease development. He uses various biophysical approaches such as AFM, fluorescence, and NMR to understand the structural details of neurotoxic oligomeric forms of these two proteins.
Dr. Rajadas is also directing the Biomaterials and Advanced Drug Delivery Laboratory at Stanford University. This center has been involved in transforming biophysical ideas into biomaterial and drug delivery technologies. These technologies include microencapsulation of drugs, vascular grafts, bio-implants, development of small molecule and protein-based drugs, regeneration of nerve and cardiovascular tissues, and wound healing applications.
Before moving to Stanford, he served as the founding chair of the Bio-organic and Neurochemistry Division at one of India’s national laboratories, Central Leather Research Institute Chennai, India, where he was responsible for both the organization and management of the division.
Selected Honors and Awards
- 2012 SPARK grant award along with Mark Nicolls
- 2012 SPARK grant award along with Bingwei Lu
- 2012 SPARK grant award along with David Stevenson
- 2011 SPARK grant award along with Mark Nicolls and Alfred Lane
- 2009 SPARK grant award along with Geoffrey C. Gurtner
- 2002 Nominee: Titular Membership of IUPAC
- 2001 Nominee: Fellow Committee of IUPAC (Chemistry) for Human Health, India
- 2000-2002 Nominee: Shanthi Swarub Bhatnagar Award, Council of Scientific and Industrial Research, India
- 1999 TANSA Award, Government of Tamil Nadu, India
- 1998-2001 Nominee: Swarnajayanthi Award, Department of Sciences & Technology, India
- 1996 Young Scientist Award in Chemistry, Council of Scientific and Industrial Research, India
- 1996 Visiting Scientist, ETH, Zürich, Switzerland
- 1990 CNRS fellowship, University of St. Jerome, Marseilles, France
- 1984 Department of Atomic Energy Fellowship for Graduate Studies, India
Professional Experience
- Founding Director (2010 - Present)
Biomaterials and Advanced Drug Delivery Laboratory (bioADD)
Stanford University School of Medicine, Stanford, California
- Assistant Director (2013-Present)
Cardiovascular Pharmacology Division, Cardiovascular Institute
Stanford University School of Medicine, Stanford, California
- Lecturer (2012 - Present)
Department of Neurology and Neurological Sciences
Stanford University School of Medicine, Stanford, California
- Instructor (2007 - 2012)
Department of Neurology and Neurological Sciences
Stanford University School of Medicine, Stanford, California
- Consulting Professor (2005 - 2007)
Department of Chemical Engineering
Stanford University, Stanford, California
- Visiting Professor (2003 - 2005)
Department of Chemical Engineering, Department of Biological Sciences
Stanford University, Stanford, California
- Visiting Scientist (1998 - 2002)
National Institute of Aging, National Institutes of Health
Baltimore, Maryland
- Head and Founding Chair (1997- 2007)
Bioorganic and Neurochemistry Laboratory
Council of Scientific and Industrial Research, Central Leather Research Institute
Chennai, India
Recent Publications |
Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications. Sun W, Araci Z, Inayathullah M, Manickam S, Zhang X, Bruce MA, Peter Marinkovich M, Lane AT, Milla C, Rajadas J*, Butte MJ. Acta Biomater. 2013 May 3. doi:pii: S1742-7061(13)00226-2. 10.1016/j.actbio.2013.04.045. PMID: 23648574
Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42). Rajadas J*, Sun W, Li H, Inayathullah M, Cereghetti D, Tan A, de Mello Coelho V, Chrest FJ, Kusiak JW, Smith WW, Taub D, Wu JC, Rifkind JM. PLoS One. 2013;8(3):e58194. PMID: 23505467
Nanotechnology-based gene-eluting stents. Goh D, Tan A, Farhatnia Y, Rajadas J, Alavijeh MS, Seifalian AM. Mol Pharm. 2013 Apr 1;10(4):1279-98. PMID: 23394068
Inception to actualization: next generation coronary stent coatings incorporating nanotechnology. Tan A, Farhatnia Y, de Mel A, Rajadas J, Alavijeh MS, Seifalian AM. J Biotechnol. 2013 Mar 10;164(1):151-70. PMID: 23376617
Pathogenesis of Abeta Oligomers in Synaptic Failure. Sivanesan S, Tan A, Rajadas J. Curr Alzheimer Res. 2012 Oct 2. PMID: 23036017
Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis. Kurnellas MP, Brownell SE, Su L, Malkovskiy AV, Rajadas J, Dolganov G, Chopra S, Schoolnik GK, Sobel RA, Webster J, Ousman SS, Becker RA, Steinman L, Rothbard JB. J Biol Chem. 2012 Oct 19;287(43):36423-34. PMID: 22955287
Biochemical engineering nerve conduits using peptide amphiphiles. Tan A, Rajadas J, Seifalian AM. J Control Release. 2012 Aug 15;163(3):342-352. PMID: 22910143
Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer. Tan A, Madani SY, Rajadas J, Pastorin G, Seifalian AM. J Nanobiotechnology. 2012 Jul 31;10:34. PMID: 22849373
Exosomes as nano-theranostic delivery platforms for gene therapy. Tan A, Rajadas J, Seifalian AM. Adv Drug Deliv Rev. 2012 Jul 20. PMID: 22820532
Stem cell niches for skin regeneration. Wong VW, Levi B, Rajadas J, Longaker MT, Gurtner GC. Int J Biomater. 2012 Jun 3.PMID: 22701121
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines. Yu W, Polepalli J, Wagh D, Rajadas J, Malenka R, Lu B. Hum Mol Genet. 2012 Mar 15;21(6):1384-90. PMID: 22156579
Structural preferences of Aβ fragments in different micellar environments. Sambasivam D, Sivanesan S, Ashok BS, Rajadas J. Neuropeptides. 2011 Dec;45(6):369-76. PMID: 22019176
Pullulan Hydrogels Improve Mesenchymal Stem Cell Delivery into High-Oxidative-Stress Wounds. Wong VW, Rustad KC, Glotzbach JP, Sorkin M, Inayathullah M, Major MR, Longaker MT, Rajadas J, Gurtner GC. Macromol Biosci. 2011 Nov 10;11(11):1458-66. PMID: 21994074
Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Rustad KC, Wong VW, Sorkin M, Glotzbach JP, Major MR, Rajadas J, Longaker MT, Gurtner GC. Biomaterials. 2012 Jan;33(1):80-90. PMID: 21963148
Quantum dots and carbon nanotubes in oncology: a review on emerging theranostic applications in nanomedicine. Tan A, Yildirimer L, Rajadas J, De La Peña H, Pastorin G, Seifalian A. Nanomedicine (Lond). 2011 Aug;6(6):1101-14. PMID: 21955079
Vascular anastomosis using controlled phase transitions in poloxamer gels. Chang EI, Galvez MG, Glotzbach JP, Hamou CD, El-Ftesi S, Rappleye CT, Sommer KM, Rajadas J, Abilez OJ, Fuller GG, Longaker MT, Gurtner GC. Nature Medicine. 2011;17(9):1147-52. PMID: 21873986
Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution. Rajadas J, Liu CW, Novick P, Kelley NW, Inayathullah M, Lemieux MC, Pande VS. PLoS One. 2011;6(7):e21776. PMID: 21799748
Adipose tissue-derived stem cells display a proangiogenic phenotype on 3D scaffolds. Neofytou EA, Chang E, Patlola B, Joubert LM, Rajadas J, Gambhir SS, Cheng Z, Robbins RC, Beygui RE. J Biomed Mater Res A. 2011;98(3):383-93. PMID: 21630430
Efficient gene delivery of primary human cells using peptide linked polyethylenimine polymer hybrid. Dey D, Inayathullah M, Lee AS, LeMieux MC, Zhang X, Wu Y, Nag D, De Almeida PE, Han L, Rajadas J, Wu JC. Biomaterials. 2011;32(20):4647-58.PMID: 21477858
Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing. Wong VW, Rustad KC, Galvez MG, Neofyotou E, Glotzbach JP, Januszyk M, Major MR, Sorkin M, Longaker MT, Rajadas J, Gurtner GC. Tissue Eng Part A. 2011;17(5-6):631-44. PMID: 20919949
A matrix micropatterning platform for cell localization and stem cell fate determination. Huang NF, Patlolla B, Abilez O, Sharma H, Rajadas J, Beygui RE, Zarins CK, Cooke JP. Acta Biomater. 2010;6(12):4614-21. PMID: 20601236
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM. J Clin Invest. 2010;120(5):1774-85. PMID: 20407211
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Rufibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, Kaye JA, Lemere CA, Leszek J, Li G, Peskind ER, Quinn JF, Yesavage JA, Ghiso JA, Wyss-Coray T. Proc Natl Acad Sci U S A. 2009;106(29):12145-50.PMID: 19581601
