Biomaterials and Advanced Drug Delivery

Dr. Jayakumar Rajadas, Ph.D.


Phone: (650) 724-6806
Lab: (650) 724-7710, Fax: (650) 724-4948
Email » [jayraja]

CAP profile

Director - Biomaterials and Advanced Drug Delivery Laboratory (BioADD)
Assistant Director - Cardiovascular Pharmacology Division, Cardiovascular Institute
Stanford University School of Medicine

Dr. Rajadas is currently working on the molecular mechanism of neurodegenerative disorders caused by aggregated tau and abeta proteins-proteins that are synergically involved in Alzheimer’s disease development. He uses various biophysical approaches such as AFM, fluorescence, and NMR to understand the structural details of neurotoxic oligomeric forms of these two proteins.

Dr. Rajadas is also directing the Biomaterials and Advanced Drug Delivery Laboratory at Stanford University. This center has been involved in transforming biophysical ideas into biomaterial and drug delivery technologies. These technologies include microencapsulation of drugs, vascular grafts, bio-implants, development of small molecule and protein-based drugs, regeneration of nerve and cardiovascular tissues, and wound healing applications.

Before moving to Stanford, he served as the founding chair of the Bio-organic and Neurochemistry Division at one of India’s national laboratories, Central Leather Research Institute Chennai, India, where he was responsible for both the organization and management of the division.

Selected Honors and Awards

Professional Experience

Selected Recent Publications

Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sun W, Lee S, Huang X, Liu S, Inayathullah M, Kim KM, Tang H, Ashford JW, Rajadas J. Scientific Reports 2016 6, 34784.

Screening of NCI DTP library to identify new drug candidates for Borrelia burgdorferi. Pothineni VR, Wagh D, Babar MM, Inayathullah M, Watts RE, Kim KM, Solow-Cordero D, Tayebi L, Gurjarpadhye AA, Parekh MB, Rajadas J. J Antibiotics 2016 (Accepted).

Enhanced electrochemical sensing with carbon nanotubes modified with bismuth and magnetic nanoparticles in a lab-on-a-chip (Ferrochip). Jothimuthu P, Hsu JL, Chen R, Inayathullah M, Pothineni VR, Jan A, Gurtner GC, Rajadas J, Nicolls MR. ChemNanoMat 2016, 2, 904-910.

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening. Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero D, Kim KM, Samineni A, Parekh M, Tayebi L, Rajadas J. Drug Design, Development and Therapy. 2016, 10, 1307–1322. PMID: 27103785.

Transdermal Delivery of Functional Collagen Via Polyvinylpyrrolidone Microneedles. Sun W, Inayathullah M, Manoukian MA, Malkovskiy AV, Manickam S, Marinkovich MP, Lane AT, Tayebi L, Seifalian AM, Rajadas J. Annals of Biomedical Engineering, 2015. PMID: 26066056

A Thermo-sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies. Sinha SR, Nguyen LP, Inayathullah M, Malkovskiy A, Habte F, Rajadas J, Habtezion A. Gastroenterology. 2015. 149(1):52-55. PMID: 25863215

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition. Wagh D, Pothineni VR, Inayathullah M, Liu S, Kim KM, Rajadas J. Drug Design, Development and Therapy. 2015, 9:805-816. PMID: 25709405

Transdermal deferoxamine prevents pressure-induced diabetic ulcers. Duscher D, Neofytou E, Wong VW, Maan ZN, Rennert RC, Inayathullah M, Januszyk M, Rodrigues M, Malkovskiy AV, Whitmore AJ, Walmsley GG, Galvez MG, Whittam AJ, Brownlee M, Rajadas J, Gurtner GC. Proc Natl Acad Sci U S A. 2015, 112(1):94-9. PMID: 25535360

[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction, Serpooshan V, Sivanesan S, Huang X, Mahmoudi M, Malkovskiy AV, Zhao M, Inayathullah M, Wagh D, Zhang XJ, Metzler S, Bernstein D, Wu JC, Ruiz-Lozano P, Rajadas J, Biomaterials, 2015, 37:289-98. PMID: 25443792

Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles. Jiang X, Malkovskiy AV, Tian W, Sung YK, Sun W, Hsu JL, Manickam S, Wagh D, Joubert LM, Semenza GL, Rajadas J, Nicolls MR. Biomaterials. 2014 Jan;35(2):803-13. PMID: 24161166

The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction. Serpooshan V, Zhao M, Metzler SA, Wei K, Shah PB, Wang A, Mahmoudi M, Malkovskiy AV, Rajadas J, Butte MJ, Bernstein D, Ruiz-Lozano P. Biomaterials. 2013 34(36):9048-55. PMID: 23992980.

Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension. Tian W, Jiang X, Tamosiuniene R, Sung YK, Qian J, Dhillon G, Gera L, Farkas L, Rabinovitch M, Zamanian R, Inayathullah M, Fridlib M, Rajadas J, Peters-Golden M, Voelkel NF, Nicolls MR. Science Trans Med. 2013, 5(200):200ra117. PMID: 23986401.

Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications. Sun W, Araci Z, Inayathullah M, Manickam S, Zhang X, Bruce MA, Peter Marinkovich M, Lane AT, Milla C, Rajadas J, Butte MJ. Acta Biomater. 2013 9(8):7767-74. PMID: 23648574

Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Rustad KC, Wong VW, Sorkin M, Glotzbach JP, Major MR, Rajadas J, Longaker MT, Gurtner GC. Biomaterials. 2012 Jan;33(1):80-90. PMID: 21963148

Vascular anastomosis using controlled phase transitions in poloxamer gels. Chang EI, Galvez MG, Glotzbach JP, Hamou CD, El-Ftesi S, Rappleye CT, Sommer KM, Rajadas J, Abilez OJ, Fuller GG, Longaker MT, Gurtner GC. Nature Medicine. 2011;17(9):1147-52. PMID: 21873986

View complete list of publications (188)»

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