Biomaterials and Advanced Drug Delivery

Dr. Jayakumar Rajadas, Ph.D.


Phone: (650) 724-6806
Lab: (650) 724-7710, Fax: (650) 724-4948
Email » [jayraja]

CAP profile

Director - Biomaterials and Advanced Drug Delivery Laboratory (BioADD)
Assistant Director - Cardiovascular Pharmacology Division, Cardiovascular Institute
Stanford University School of Medicine

Adjunct Professor
Department of Bioengineering and Therapeutic Sciences
University of California San Francusco (UCSF) School of Pharmacy

Dr. Rajadas is currently working on the molecular mechanism of neurodegenerative disorders caused by aggregated tau and abeta proteins-proteins that are synergically involved in Alzheimer’s disease development. He uses various biophysical approaches such as AFM, fluorescence, and NMR to understand the structural details of neurotoxic oligomeric forms of these two proteins.

Dr. Rajadas is also directing the Biomaterials and Advanced Drug Delivery Laboratory at Stanford University. This center has been involved in transforming biophysical ideas into biomaterial and drug delivery technologies. These technologies include microencapsulation of drugs, vascular grafts, bio-implants, development of small molecule and protein-based drugs, regeneration of nerve and cardiovascular tissues, and wound healing applications.

Before moving to Stanford, he served as the founding chair of the Bio-organic and Neurochemistry Division at one of India’s national laboratories, Central Leather Research Institute Chennai, India, where he was responsible for both the organization and management of the division.

Selected Honors and Awards

Professional Experience

Selected Recent Publications

Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptide analogues crosslinked to an injectable collagen matrix. Lee AS, Inayathullah M, Lijkwan M, Zhao X, Sun W, Park S, Hong W, Parekh M, Malkovskiy A, Lau E, Qin X, Pothineni VR, Sanchez-Freire V, Zhang W, Kooreman N, Ebert A, Chan C, Nguyen P, Rajadas J*, Wu JC. Nature Biomedical Engineering, 2018, 2(2) 104-113. doi: 10.1038/s41551-018-0191-4

PEG/Dextran Double Layer Influences Fe Ion Release and Colloidal Stability of Iron Oxide Nanoparticles. Mohammadi MR, Malkovskiy AV, Jothimuthu P, Kim KM, Parekh M, Inayathullah M, Zhuge Y, Rajadas J*. Scientific Reports. 2018, 8(1):4286. doi: 10.1038/s41598-018-22644-8. PMID: 29523826.

Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation. Hsu JL, Manouvakhova OV, Clemons KV, Inayathullah M, Tu AB, Sobel RA, Tian A, Nazik H, Pothineni VR, Pasupneti S, Jiang X, Dhillon GS, Bedi H, Rajadas J, Haas H, Aurelian L, Stevens DA, Nicolls MR. Sci Transl Med. 2018, 10(429). doi: 10.1126/scitranslmed.aag2616. PMID: 29467298

Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ. Sci Transl Med. 2017, 9(407). doi: 10.1126/scitranslmed.aad4000. PMID: 28904225

Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair. Hu MS, Walmsley GG, Barnes LA, Weiskopf K, Rennert RC, Duscher D, Januszyk M, Maan ZN, Hong WX, Cheung AT, Leavitt T, Marshall CD, Ransom RC, Malhotra S, Moore AL, Rajadas J, Lorenz HP, Weissman IL, Gurtner GC, Longaker MT. JCI Insight. 2017, 2(19). doi: 10.1172/jci.insight.96260. PMID: 28978794

Nanomaterials Engineering For Drug Delivery: Hybridization Approach. Mohammadi MR, Nojoomi A, Mozafari M, Dubnika A, Inayathullah M, Rajadas J*. J Mater Chem B. 2017, 5, 3995-4018. doi: 10.1039/C6TB03247H

Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sun W, Lee S, Huang X, Liu S, Inayathullah M, Kim KM, Tang H, Ashford JW, Rajadas J*. Scientific Reports 2016, 6, 34784 doi:10.1038/srep34784. PMID: 27708431.

Screening of NCI DTP library to identify new drug candidates for Borrelia burgdorferi. Pothineni VR, Wagh D, Babar MM, Inayathullah M, Watts RE, Kim KM, Solow-Cordero D, Tayebi L, Gurjarpadhye AA, Parekh MB, Rajadas J*. J Antibiotics 2017, 70(3), 308-312. doi: 10.1038/ja.2016.131. PMID: 27826144.

Enhanced electrochemical sensing with carbon nanotubes modified with bismuth and magnetic nanoparticles in a lab-on-a-chip (Ferrochip). Jothimuthu P, Hsu JL, Chen R, Inayathullah M, Pothineni VR, Jan A, Gurtner GC, Rajadas J*, Nicolls MR. ChemNanoMat. 2016, 2, 904-910. PMID: 27857882 doi: 10.1002/cnma.201600174. Cover Page: Back Cover, ChemNanoMat 9/2016, page 921.

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening. Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero D, Kim KM, Samineni A, Parekh M, Tayebi L, Rajadas J. Drug Design, Development and Therapy. 2016, 10, 1307–1322. PMID: 27103785.

Transdermal Delivery of Functional Collagen Via Polyvinylpyrrolidone Microneedles. Sun W, Inayathullah M, Manoukian MA, Malkovskiy AV, Manickam S, Marinkovich MP, Lane AT, Tayebi L, Seifalian AM, Rajadas J. Annals of Biomedical Engineering, 2015. PMID: 26066056

A Thermo-sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies. Sinha SR, Nguyen LP, Inayathullah M, Malkovskiy A, Habte F, Rajadas J, Habtezion A. Gastroenterology. 2015. 149(1):52-55. PMID: 25863215

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition. Wagh D, Pothineni VR, Inayathullah M, Liu S, Kim KM, Rajadas J. Drug Design, Development and Therapy. 2015, 9:805-816. PMID: 25709405

Transdermal deferoxamine prevents pressure-induced diabetic ulcers. Duscher D, Neofytou E, Wong VW, Maan ZN, Rennert RC, Inayathullah M, Januszyk M, Rodrigues M, Malkovskiy AV, Whitmore AJ, Walmsley GG, Galvez MG, Whittam AJ, Brownlee M, Rajadas J, Gurtner GC. Proc Natl Acad Sci U S A. 2015, 112(1):94-9. PMID: 25535360

[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction, Serpooshan V, Sivanesan S, Huang X, Mahmoudi M, Malkovskiy AV, Zhao M, Inayathullah M, Wagh D, Zhang XJ, Metzler S, Bernstein D, Wu JC, Ruiz-Lozano P, Rajadas J, Biomaterials, 2015, 37:289-98. PMID: 25443792

Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension. Tian W, Jiang X, Tamosiuniene R, Sung YK, Qian J, Dhillon G, Gera L, Farkas L, Rabinovitch M, Zamanian R, Inayathullah M, Fridlib M, Rajadas J, Peters-Golden M, Voelkel NF, Nicolls MR. Science Trans Med. 2013, 5(200):200ra117. PMID: 23986401.

View complete list of publications (215)»

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